A patient derived xenograft model of cervical cancer and cervical dysplasia
نویسندگان
چکیده
منابع مشابه
Cervical Cancer Patient-Derived Orthotopic Xenograft (PDOX) Is Sensitive to Cisplatinum and Resistant to Nab-paclitaxel.
BACKGROUND Cervical cancer is a world-wide problem that requires transformative therapeutic strategies. We have previously developed patient-derived orthotopic xenograft (PDOX) nude-mouse models of this disease. In the present report, we demonstrate that the standard drug, cisplatinum (CDDP), is highly-effective while the new, highly-touted agent, nab-paclitaxel (NAB-PTX) is ineffective. MATE...
متن کاملEstablishment of a Patient-Derived Orthotopic Xenograft (PDOX) Model of HER-2-Positive Cervical Cancer Expressing the Clinical Metastatic Pattern
Squamous cell carcinoma of the cervix, highly prevalent in the developing world, is often metastatic and treatment resistant with no standard treatment protocol. Our laboratory pioneered the patient-derived orthotopic xenograft (PDOX) nude mouse model with the technique of surgical orthotopic implantation (SOI). Unlike subcutaneous transplant patient-derived xenograft (PDX) models, PDOX models ...
متن کاملCervical cancer
سرویکس یا گردن رحم قسمتی از اندام تولید زنانه است که دهانه آن به داخل واژن باز می شود. بعضی اعمال آن عبارتند از : تولید مواد نرم کننده واژن - تولید موکوس که کمک به حرکت اسپرم می کند- حفظ جنین در رحم در طول بارداری
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Background: Genistein (GEN), a naturally occurring flavonoid present in soy bean, has attracted scientific interest for its possible benefits in cancer. Objective: The potential immunomodulatory effects of genistein on the immune system and against TC-1 tumor cell line were evaluated in adult female C57BL/6 mice. Methods: Mice were treated with GEN 10 days before to 10 days after the tumor indu...
متن کاملAge and Ethnic Differences in the Occurrence of Cervical Dysplasia, Cervical Cancer, and Cervical Cancer Deaths in Suriname
Background: Updated information on the frequency of premalignant cervical lesions in Suriname is scant, while currently available data on the age and ethnic distribution of cervical dysplasia, cervical carcinoma, and cervical cancer deaths are inconsistent and conflicting. For these reasons, we assessed these topics using a retrospective cohort approach. Methods and Findings: Using secondary da...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2018
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0206539